Emerging and remerging infections (ERIs) are a major threat to global health today. The world needs to be prepared to handle an outbreak anytime as ERIs occur unpredictably, often causing serious morbidity, mortality as well as economic losses. Preparation requires surveillance so as to detect outbreaks and nip them before they spiral out of control
This project aims to identify arboviral causes of acute febrile illness (AFI) in Kibera, Nairobi.
This is a cross-sectional study on patients with undifferentiated fever in three health facilities in Kibera informal settlement, Nairobi city, Kenya. Clinicians will obtain informed consent from patients who meet the inclusion criteria. Sociodemographic and clinical data, as well as blood and urine samples, will be collected from patients with fever. Samples will be analyzed for current or previous infection with flaviviruses (e.g. dengue), alphaviruses (e.g. Chikungunya), and bunyaviruses (e.g. Rift valley fever). In addition, the samples will be analyzed using next-generation sequencing to detect any other viruses in the samples.
This study is expected to proportion of acute febrile illness that is due to arboviruses. Any novel or emerging viruses will also be identified and characterized. This information will help inform surveillance efforts as well selection and development of appropriate diagnostic assays and vaccine targets for common arboviral infections in the study area and beyond.
This project (TMA2017CDF-1865) is part of the EDCTP2 programme supported by the European Union